review

Senolytic Supplements for Sale: Where to Buy 2019

Senolytic supplements have been of extreme interest lately to the public as research continues to pile up showing some pretty awesome benefits.

Specifically, senolytics are proven to have powerful anti-aging properties that can lead to longer lifespans and, better yet, much longer 'health spans' - allowing for many more years of youthful cognitive functioning and less chance of debilitating age related diseases.

In this article we'll discuss how senolytic supplements can work their magic (the underlying process and how the aging process is involved) as well as look into where we will able to buy them and properly use them for peak benefits.

Senolytics and Senescent Cells

As you grow older more and more of your body's cells become senescent.

This is bad news because senescent cells release a plethora of negative chemicals that cause other cells in it's vicinity to become senescent as well, not supporting the tissue in which they live and not dividing to make more healthy cells.

This means your tissue decreases in function, inflammatory processes are kicked into high gear - possibly leading to the many age related diseases and maladies our aging population is fighting today.

In fact, we see hardly any senescent cells in younger populations, however, after 40 to 50 years, we see these numbers start to go up and up at a very alarming and compounding rate.

This skyrocketing rate is largely attributable to the fact that as we age, our bodies immune system does not clear these cells nearly as efficiently as it when we were younger.

Although the buildup of these cells over time is unavoidable there are a few different ways to reduce senescence, all of which are crucial to those wanting to increase their healthspan dramatically.

Lifestyle changes have been shown to be effective at clearing out senescent cells…

The most widely used lifestyle change with very notable benefits regarding the removal of these cells is a switch up in dieting routine.

No autophagy induced vs. authophagy induced through caloric restriction

No autophagy induced vs. authophagy induced through caloric restriction

Namely, occasional fasting for 3 to 4 days (every month or so) is thought to get rid of accumulated senescent cells…

Fasting works in this way through a mechanism called hormesis, providing a low-level stressor that allows your body to prepare and build a response that can more easily deal with much more formidable stressors.

Further, during this hormetic response by the body, autophagy (cellular regeneration) occurs as damaged cells die and are cleared.

Supplementation to Clear Senescent Cells

Because this lifestyle change, working fasting into your workweek on occasion, can be daunting and draining, some prefer senolytic supplements to help clear away senescent cells much to the same effect.

Although at one point it was thought that resveratrol (famously found in red wine) was a superior compound in anti-aging, it is now understood that it only dampens what the senescent cells release (those negative chemicals we talked about earlier) while not actually clearing away those cells.

Fortunately, newer research has shown that where resveratrol fails (although not bad for you, just not as good as it could be)…

The new compound spermidine excels

Effectively clearing away senescent cells just as well if not better than a 4 day fast used monthly.

So while it is much more widely available to consumers, resveratrol is not a true senolytic supplement or nearly as effective as spermidine which is notoriously scarce and more costly.

>>You can check the current pricing and availability here<<

Overall, what I think on compounds like this, which we are just learning how amazingly powerful they are in their ability to clear away these senescent cells - is that it is much more well suited to called them pro-health span supplements rather than anti-aging supplements.

I say this because that is where the true value in things like spermidine come about and to quote the brilliant Judith Campisi, Ph.D. “...dying of cancer is no fun but I think many people fear even more, is this loss of cognition… We will die but I think what we mostly fear is actually where the quality of life is very poor.”

Drinkade Review: Does Drinkade Really Work?

My Drinkade review comes after a blinded-study of Drinkade conducted a week ago. Our Drinkade review was done experiment-style and used a placebo (just like with our hangover winner MixFix RECOVER) to give you guys more accurate results (what I strive for)...

This is because, and I’m sure you can agree when I tell you…

A review tainted by expectations is hardly a trustworthy review at all.

The problem is most reviewers think they are above the placebo effect and expensive hype brands push.

It took me years of trying subpar products before I started to master “semi-scientific” reviewing…

And these blinded-reviews instantly impacted confidence in my findings. People really appreciate the scientific approach and come to me to review new products all the time now!

I am ALWAYS wary of hangover remedies after having tried dozens and only finding 2 that actually work really well (1. MixFix RECOVER 2. Thrive+).

So, even though I am sticking with MixFix, readers asked for a Drinkade review specifically.

In this post I will:

1. break down the ingredients
2. detail my experience
3. give an overall recommendation 

Drinkade Ingredients Review

The ingredients that Drinkade lists include some of the old mainstays in hangover prevention.

And while many of these ingredients are widely used in hangover products...

Drinkade suffers in this regard because it includes some ingredients that have not been found to help hangover symptoms (such as common Aloe Vera)...

DHM extract from oriental raisin trees has been shown to greatly reduce hangover symptoms.

DHM extract from oriental raisin trees has been shown to greatly reduce hangover symptoms.

While shunning revolutionary new ingredients that are proven effective (such as DHM and high levels of Thiamine).

In this way, it seems like Drinkade is just following what's been done by old companies rather than delve into the emerging science as only a handful of new companies have been.

Drinkade does include a few solid ingredients that are shown to reduce hangover symptoms...

These include Milk Thistle, a B Vitamin Complex (although some B vitamins are much more important than others), and Potassium as an electrolyte.

My Drinkade Experience

I take my reviews rather seriously, as you may know, so tried for a blind study.

This meant having a friend prepare 2 cups, one being a placebo he made with some sort of lime flavoring powder (I was told after the experiment), and the other being the real deal.

Since I had never tried Drinkade before, I wouldn't be able to be certain which drink was the actual product.

We ran this blind test 2 nights, 2 days apart... with myself not knowing which day I got Drinkade vs. the placebo.

Don't judge me...

Don't judge me...

Each night I drank 10 shots of vodka over 4 hours and drank a liter of water before bed (as I do any night I drink alcohol).

I took the Drinkade or the placebo as recommended each night - about 20 to 30 minutes before starting to drink.

The next morning I rated my hangover on the 3 most common hangover symptoms…

A) Nausea B) Grogginess/Fatigue C) Headache

I used a 0 - 10 scale with 0 being no symptoms and 10 being normally expected hangover symptoms for the amount drank.

Then the ratings for each were averaged for a final result.

I've used the same design with multiple subjects (although not blinded) when comparing MixFix RECOVER capsules and Thrive+ capsules in this article.

Results of my Review

After the 2 nights were over and I had rated each morning/afternoon - the results were in!

I could finally see which average rating paired with the Drinkade vs. the placebo...

And Drinkade beat the placebo by 3 points!!

The placebo I rated an 8 of 10 (meaning I reported feeling about the same as I would expect given the amount drank)...

Seeing that I didn't rate it a 10 speaks to the power the placebo effect can have at times.

Drinkade I rated a 5 of 10 (meaning I felt a heck of a lot better than expected).

While this rating shows this pre-drink remedy may not work as well as the post-drinking capsules we've reviewed here before...

It is impressive to see a preemptive strike like Drinkade have a 3 point reduction in symptoms because I was skeptical of these types of hangover remedies in the past.

Overall Recommendation

Even though Drinkade made a good dent in my hangover...

Products like Thrive+ and MixFix RECOVER (the new champion in my book) by LZR LABS provide much greater relief from what I've seen.

This is especially true if nausea is one of your main hangover symptoms!

So IMO Drinkade is pretty good but you're better off with one of the post-drinking capsules covered above to get the DHM (game-changer), and adequate Thiamin to really squash your rough mornings.

^Current hangover test winner of 2018

^Current hangover test winner of 2018

Hope that helps and as always, Cheers :)

P.S. If you're a regular reader and want me to review another hangover remedy let me know!

We'll pick one with the most requests and see if we can dethrone MixFix RECOVER :P

Tomatidine Supplement Availability and Dosage: Is the Tomatidine for Sale Worth It?

Tomatidine supplements like capsules, powders, and tomatidine tablets are - in my opinion - the future of wellness enhancement given recent research.

So, I reached out to the only legitimate tomatidine lab and supplier in the U.S. and did a deep dive into dosage calculations to bring you the best info on this exciting new compound. 

What Can Tomatidine Do?

+30% STRENGTH AND +10% LEAN MUSCLE

According to research reported here by Science Daily.

Come-Back Fit Pro Mike Hardy

Come-Back Fit Pro Mike Hardy

"You know how ego-crushing it is to see yourself physically decline with age?" Said come-back fitness pro Mike Hardy.

"I've been there."

"That's why I take Ursolodine year round."

"Once you start on it - the fatigue, the muscle loss, the frustration - it all fades away. It's like nothing you've ever experienced."

Hardy summarized his support by saying:

"If you can grasp the next thing I'm about to say - you'll agree that interventions like tomatidine will completely transform your life..."

"90% of people over the age of 35 lose enough muscle every year to burn off an additional 4 pounds of body fat.

So you not only lose the only thing on your body that creates shape, tone, and strength—you also gain more fat every year, even if your calories stay the same."

"That's a reality check, and if you surround yourself with naysayers who are constantly talking about growing old, all their aches and pains, and how life is just down hill after 40—LEAVE! - Take control, because now it's possible."


When reached for comment, LZR Labs spokesperson Lindsey Bradford had this to say about their flagship tomatidine supplement...

"Ursolodine was a collaborative effort in the end."

"1,250 customers helped Ursolodine come to be by preordering and showing huge support for the product. Within hours of launching we sold out our first batch ever"

Potential customers join a waitlist when downtime occurs between batches (sometimes up to 4 weeks).

These waitlisters opt-in to get alerts about new stock via email or even text.

However, at least one customer we spoke with suspected the alert system plays favorites... notifying high-quantity repeat customers and small supplement stores preferentially.

Steve Markman, an avid crossfitter from Florida, noted over the phone:

“Within 30 minutes of my alert this past weekend the stock had already vanished online... [But] my cousin in Atlanta always orders in bulk for his shop and got an alert a full 2 hours earlier than I did.”

At this time Ursolodine isn’t available as a subscription plan, keeping a relatively exclusive list of customers on edge for the only tomatidine based supplement available in the U.S.

From this glance into the market we can see that availability is definitely an issue.

Analyzing Tomatidine Dosage

In studies on tomatidine, mice were given 50mg per kg of bodyweight.

Tomatidine Dosage

With the mice at 0.15kg, they were receiving 7.5mg daily for 8 weeks.

Using the Journal of Clinical Pharmacy standards (FDA approved for calculating human dose conversions), we get a clear idea of proper tomatidine dosage.

For a 150 lb. man to see results similar to those we’ve seen in the research, he would need to dose his tomatidine between 90 - 110 mg daily.

This relatively low dosing protocol makes tomatidine “significantly more potent than ursolic acid” Christopher Adams, M.D., Ph.D. and associate professor with the University of Iowa told Science Daily.

Adams also reported that tomatidine has slightly different mechanisms of action compared to ursolic acid, leading some researchers to hypothesize that the two compounds could work together synergistically, yielding even greater results. 

Indeed, this cooperation between the two adaptogens is what prompted LZR Labs to combine them in their latest adaptogen blend according to Bradford in response to an email follow-up. 

Learn more or start your order of Ursolodine here with LZR Labs.