Senolytic supplements have been of extreme interest lately to the public as research continues to pile up showing some pretty awesome benefits.
Specifically, senolytics are proven to have powerful anti-aging properties that can lead to longer lifespans and, better yet, much longer 'health spans' - allowing for many more years of youthful cognitive functioning and less chance of debilitating age related diseases.
In this article we'll discuss how senolytic supplements can work their magic (the underlying process and how the aging process is involved) as well as look into where we will able to buy them and properly use them for peak benefits.
Senolytics and Senescent Cells
As you grow older more and more of your body's cells become senescent.
This is bad news because senescent cells release a plethora of negative chemicals that cause other cells in it's vicinity to become senescent as well, not supporting the tissue in which they live and not dividing to make more healthy cells.
This means your tissue decreases in function, inflammatory processes are kicked into high gear - possibly leading to the many age related diseases and maladies our aging population is fighting today.
In fact, we see hardly any senescent cells in younger populations, however, after 40 to 50 years, we see these numbers start to go up and up at a very alarming and compounding rate.
This skyrocketing rate is largely attributable to the fact that as we age, our bodies immune system does not clear these cells nearly as efficiently as it when we were younger.
Although the buildup of these cells over time is unavoidable there are a few different ways to reduce senescence, all of which are crucial to those wanting to increase their healthspan dramatically.
Lifestyle changes have been shown to be effective at clearing out senescent cells…
The most widely used lifestyle change with very notable benefits regarding the removal of these cells is a switch up in dieting routine.
Namely, occasional fasting for 3 to 4 days (every month or so) is thought to get rid of accumulated senescent cells…
Fasting works in this way through a mechanism called hormesis, providing a low-level stressor that allows your body to prepare and build a response that can more easily deal with much more formidable stressors.
Further, during this hormetic response by the body, autophagy (cellular regeneration) occurs as damaged cells die and are cleared.
Supplementation to Clear Senescent Cells
Because this lifestyle change, working fasting into your workweek on occasion, can be daunting and draining, some prefer senolytic supplements to help clear away senescent cells much to the same effect.
Although at one point it was thought that resveratrol (famously found in red wine) was a superior compound in anti-aging, it is now understood that it only dampens what the senescent cells release (those negative chemicals we talked about earlier) while not actually clearing away those cells.
Fortunately, newer research has shown that where resveratrol fails (although not bad for you, just not as good as it could be)…
The new compound spermidine excels…
Effectively clearing away senescent cells just as well if not better than a 4 day fast used monthly.
So while it is much more widely available to consumers, resveratrol is not a true senolytic supplement or nearly as effective as spermidine which is notoriously scarce and more costly.
Overall, what I think on compounds like this, which we are just learning how amazingly powerful they are in their ability to clear away these senescent cells - is that it is much more well suited to called them pro-health span supplements rather than anti-aging supplements.
I say this because that is where the true value in things like spermidine come about and to quote the brilliant Judith Campisi, Ph.D. “...dying of cancer is no fun but I think many people fear even more, is this loss of cognition… We will die but I think what we mostly fear is actually where the quality of life is very poor.”